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How is Ankylosing Spondylitis Treated?

Treatment for ankylosing spondylitis (AS) is tailored to the individual, as there is a wide variety in how AS affects different people. Treatment for AS aims to achieve several goals, including1:

  • Reducing the symptoms, such as pain and stiffness
  • Maintaining spinal flexibility and normal posture
  • Maintaining the person’s ability to work and function in daily life
  • Decreasing disease complications

Types of treatment

Treating and managing AS usually involves a combination of therapies, including:

The American College of Rheumatology (ACR), in conjunction with the Spondylitis Association of America and the Spondyloarthritis Research and Treatment Network, have created treatment guidelines for AS. NSAIDs are recommended as a first-line treatment (the first treatment tried), and the ACR recommends ongoing treatment with NSAIDs, rather than only using NSAIDs during flares. For people who continue to have active disease despite treatment with NSAIDs, the ACR recommends using biologic medications, like TNF (tumor necrosis factor) inhibitors. Treatment with SAARDs are generally not recommended, unless the individual cannot take TNF inhibitors or cannot tolerate the side effects. In addition to medications, people with AS are advised to do regular exercise, including posture exercises. Physical therapy is recommended to help manage the symptoms of the disease and help people living with AS maintain their ability to move.1

Types of surgery

While most people with AS don’t need surgery, in certain cases surgery may be necessary. The ACR guidelines recommend using surgery such as hip replacement in people who have advanced hip arthritis.1 Other surgeries that may be needed in certain people with AS include2:

  • Osteotomy – used to correct a deformity in the spine
  • Spinal fusion instrumentation – used to stabilize a weakened spine
  • Spinal decompression – used to relieve pressure on the nerves

Treatment recommendations for active versus stable ankylosing spondylitis

Treatment guidelines by the ACR recommend different approaches for people who have active AS and those whose disease is stable. For active AS, NSAIDs, biologics, and physical therapy are strongly recommended. For stable AS, the ACR conditionally recommends continuing treatment with TNF inhibitors alone, instead of both NSAIDs and TNF inhibitors. For those taking SAARDs and TNF inhibitors with stable disease, the ACR also conditionally recommends continuing treatment with TNF inhibitors alone. Physical therapy should be continued for both active and stable AS.1

Lifestyle changes

Many people with AS find they must make modifications to their lifestyle to help manage their condition and maximize their health and well-being. Lifestyle changes may take many forms, such as:

Complementary therapies

People with AS may also choose to incorporate complementary therapies along with their treatment to manage their symptoms. Some of the complementary medicine approaches for AS include:

Written by: Emily Downward | Last reviewed: February 2019
  1. Ward MM, Deodhar A, Akl EA, et al. American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis Rheumatol. 2015;68(2):282-98.
  2. Shaffrey CI. Surgery for ankylosing spondylitis. Spine Universe. Available at https://www.spineuniverse.com/conditions/spinal-arthritis/ankylosing-spondylitis/surgery-ankylosing-spondylitis. Accessed 2/13/19.