Taltz® (ixekizumab)

Reviewed by: HU Medical Review Board | Last reviewed: December 2020 | Last updated: December 2020

Taltz® (ixekizumab) is a prescription drug that is used to treat certain people with ankylosing spondylitis (AS). It is a type of biologic therapy called an interleukin 17-A (IL-17A) blocker. Biologic drugs are generally used in the treatment of AS that has not been adequately managed with prescription or over-the-counter NSAIDs (nonsteroidal anti-inflammatory drugs).1

Taltz is also approved to treat plaque psoriasis and non-radiographic axial spondyloarthritis.1

What are the ingredients in Taltz?

The active ingredient in Taltz is ixekizumab, an IL-17A blocker.1

How does Taltz work?

Taltz works by targeting IL-17A proteins, which are chemical messengers (cytokines) that are involved in the inflammatory response. People with conditions like AS have an excess or abnormal amount of inflammation and increased levels of IL-17A proteins. Taltz attaches to IL-17A proteins and stops them from causing inflammation and immune response. This can help reduce AS symptoms like pain and joint stiffness.2

What are the possible side effects of Taltz?

The most common side effects of Taltz include:1,2

  • Injection site reactions
  • Upper respiratory infections
  • Nausea
  • Fungal skin infections

Other less common side effects may include:1,2

  • Stuffy nose
  • Fungal infection in the mouth
  • Itching
  • Flu
  • Pinkeye
  • Inflammatory bowel disease
  • Swelling

These are not all the possible side effects of Taltz. Talk to your doctor about what to expect or if you experience any changes that worry you.

Things to know about Taltz

Do not use Taltz if you have symptoms of infection. Taltz can increase your risk of infection. Tell your doctor before using Taltz if you have any infection symptoms, such as fever, chills, muscle aches, cough, shortness of breath, skin sores, diarrhea, or pain with urination.1,2

Your doctor will check you for tuberculosis (TB) before you start taking Taltz. They will monitor you for signs of TB during and after your treatment. If you have TB or have had it before, your doctor may treat you for it before starting Taltz.1,2

Do not use Taltz if you have had a severe allergic reaction to Taltz. Serious allergic reaction includes swelling of the face, lips, mouth, tongue, or throat; trouble breathing; skin rash; feeling faint; or tightness in the chest or throat. If you have any of these symptoms, get emergency medical help right away.1,2

Crohn’s disease or ulcerative colitis can start or worsen with Taltz use. Tell your doctor if you have stomach pain, diarrhea, or weight loss.1,2

Do not get live vaccines while taking Taltz. Get all the vaccines you need before taking Taltz. Talk to your doctor about which vaccines are right for you.1,2

There is not enough information about Taltz and pregnancy to know if this drug is safe to use when pregnant or breastfeeding. Prior to using this drug, tell your doctor if you are pregnant, plan to become pregnant, or breastfeeding.1,2

Before taking Taltz, tell your doctor about any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Taltz.

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