Thanks for the response, Katie! Sorry to hear of your allergy to Humira, especially because it was working for you. I have opted to not go the medication route. It’s a tough one for me as I’m a nutritionist and feel like conditions often can be controlled by healthy diet and lifestyle. Because much of AS is due to inflammation, I have tried very hard to reduce it. Unfortunately, despite my efforts, I have finally succumbed to muscle relaxers and 800mg ibuprofen to control spasms and pain. This helps with my headaches a lot except in a flare which then is not enough to stop the headaches. Like you, usually once I get up and have coffee, the headaches dissipate some but they usually come on about 2am so it makes for a horrible night of sleep! Ugh! Interested to hear how other people respond as well and maybe it’s time I decide on other meds as well.